House of Blues Orlando opened in 1997 and is located in Downtown Disney West Side. The famous water tower, which founder Isaac Tigrett spotted on a train ride through the mid–west, stands over 100 feet tall and is a recognizable landmark to the Downtown Disney promenade.

Guests at the House of Blues Orlando are treated to the artwork of Mr. Imagination, including his famous Arch. In keeping with tradition, the House of Blues Orlando displays the "Crazy Quilt" and keeps a metal box of mud from the Delta Mississippi underneath its stage.